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KMID : 0371320010600030268
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Journal of the Korean Surgical Society
2001 Volume.60 No. 3 p.268 ~ p.272
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Estrogen Receptor α, β and Progesteron Receptor Expression in Gynecomastia Using Immunohistochemical Staining
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Park Sun-Cheol
Kim Kee-Hwan
Kim Jeong-Soo
An Chang-Hyeok
Jeon Hae-Myung
Lee Eun-Jung
Jung Sang-Seol
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Abstract
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Purpose: Gynecomastia is a common male breast abnormality and primarily occurs in puberty and senescence. The obvious etiological role of hormonal changes in gynecomastia, plus the discovery of estrogen receptor in normal and neoplastic breast, has spurred several investigations of ER content in male gynecomastic tissues. The results have been inconsistent and the fraction of ER-positive specimens has varied from 0∼90%.
Methods: Immunohistochemical hormonal receptor analysis using monoclonal estrogen receptor (ER) α, β and progesteron receptor (PR) was performed on the breast tissues of 58 patients with gynecomastia bet
ween January 1995 and January 2000 in the Department of Surgery, Uijongbu St. Mary’s Hospital. These results were statistically compared with clinical data.
Results: 48 cases (82.8%) were ERα positive and 55 cases (94.8%) were ERβ positive and PR positivity was noted in 55 cases (94.8%). There was negative relationship between ERα and age, PR and location.
Conclusion: This study demonstrates that intracellular steroid receptors are present in most gynecomastic tissues. Additionally, it supports the general assumption that estrogen and progesteron may be two of the hormones responsible for the development of gynecomastia.
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KEYWORD
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Gynecomastia, Estrogen receptor α, β, Progesteron receptor,
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